What does this research mean for the field?

Placental compensatory mechanisms, including decreased placental glucose utilization and increased amino acid utilization, rescue fetal growth and umbilical glucose concentrations near-term following mid-gestation SLC2A3 deficiency, although enhanced nutrient-stimulated fetal insulin secretion persists. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to investigate the effects of placental SLC2A3 RNA interference on fetal growth and metabolism throughout gestation.

April 15, 2026Journal of Animal Science

In vivo physiological ramifications of placental SLC2A3- RNA interference throughout gestation in sheep

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Authors

VKVictoria C. KennedyColorado State University ATAmelia R. TannerUniversity of Colorado Anschutz Medical Campus CLCameron S. LynchColorado State University

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Implication

Experiments demonstrate altered fetal insulin secretion and placental nutrient regulation in sheep pregnancies.

Key Points

This study aims to investigate the effects of placental SLC2A3 RNA interference on fetal growth and metabolism throughout gestation.
Generated SLC2A3-RNAi and NTS-RNAi control sheep pregnancies.
Conducted metabolic studies during surgical catheterization at near-term gestation.
Assessed uterine and umbilical blood flow, glucose uptake, and insulin secretion.
SLC2A3-RNAi pregnancies showed 29% reduced uterine glucose uptake and 40% reduced placental glucose utilization.
Increased placental amino acid carbon utilization by 76% was noted, suggesting compensatory mechanisms.
Near-term fetal insulin secretion capacity was significantly enhanced in SLC2A3-RNAi pregnancies.

Cite This Study

Kennedy et al. (2026) studied this question.

synapsesocial.com/papers/69df2c2fe4eeef8a2a6b1279 https://doi.org/10.1093/jas/skag118

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In vivo physiological ramifications of placental SLC2A3- RNA interference throughout gestation in sheep

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Cite This Study

In vivo physiological ramifications of placental SLC2A3- RNA interference throughout gestation in sheep

Discussion

Member takes

Implication

Key Points

Cite This Study

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