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To evaluate whether ovarian cancer organoids accurately represent the transcriptomic profiles of primary tumors.

April 15, 2026OrganoidOpen Access

Integrative transcriptomics defines the culture-imposed identity of ovarian cancer organoids

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To evaluate whether ovarian cancer organoids accurately represent the transcriptomic profiles of primary tumors.
Conducted transcriptomic comparison of 17 HGSOC organoids and 271 TCGA primary tumor samples.
Applied methods including variance-stabilizing transformation, ComBat batch correction, and ConsensusOV classification.
Used unsupervised hierarchical clustering and differential gene expression analysis to characterize organoid profiles.
All organoids clustered within C1, indicating a distinct transcriptional profile.
C1 organoids showed higher stromal interaction scores and enrichment in hypoxia and epithelial-to-mesenchymal transition pathways.
Organoids in C1 exhibited upregulation of mitotic spindle and G2M checkpoint genes compared to primary tumors.

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Integrative transcriptomic analysis reveals culture-driven changes in identity of ovarian cancer organoids, suggesting implications for research.

Woo et al. (2026) studied this question.

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Integrative transcriptomic analysis reveals culture-driven changes in identity of ovarian cancer organoids, suggesting implications for research.