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April 15, 2026MoleculesOpen Access

Rare-Earth Elements at the Interface of Chemistry and Cancer Therapy

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Authors

CGChristian GoldișNPNicoleta Anamaria PaşcalăuRRRoxana Racoviceanu

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Overview

This review examines the anticancer potential of rare-earth elements in cancer therapies, suggesting new treatment pathways.

Key Points

  • To review the intrinsic anticancer properties of rare-earth element-based complexes and nanostructures over the past decade.
  • Analyzed studies on rare-earth elements published in the last ten years.
  • Investigated selective cytotoxicity against malignant cells.
  • Examined mechanisms including reactive oxygen species generation and mitochondrial dysfunction.
  • Assessed the effectiveness of rare-earth compounds in in vitro and in vivo models.
  • Rare-earth elements exhibit selective toxicity towards tumor cells compared to normal tissues.
  • Molecular complexes show significant anticancer activity via interactions with DNA and biomolecules.
  • Nanostructured systems enhance drug delivery and cellular uptake, improving treatment responsiveness.
  • Different rare-earth elements vary in their levels of anticancer effects.

Cite This Study

Goldiș et al. (2026) studied this question.

synapsesocial.com/papers/69df2c50e4eeef8a2a6b153ehttps://doi.org/10.3390/molecules31081264
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