This research shows variations of 5'tRFs in brain and plasma during seizure states, suggesting their role as biomarkers for epilepsy.
These data suggest that 5'tRFs accumulate in the brain during interictal spike activity and accumulate in the plasma of individuals with epilepsy. 5'tRFs may therefore serve as accessible, diagnostic biomarkers for epilepsy.
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Soukupovà et al. (2026) studied this question.
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