Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights from a large international sicca registry

AT use and blurred vision were stronger indicators of ocular surface and tear film abnormalities than pain symptoms, and their presence merits an ophthalmology referral. Symptom-based clustering revealed varied symptom-burden groups, likely driven by underlying neurotrophic and neuropathic mechanisms, highlighting heterogeneity within sicca presentations and the need to develop phenotype-based targeted therapies.