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June 13, 2026JCR Journal of Clinical Rheumatology

Beyond the Glands: Extraglandular Manifestations Associated With Sicca Symptoms in Systemic Sclerosis

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Authors

NKNikolaos KoletsosKTKonstantinos TrentzidisNGNafsika Gerolymatou

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Overview

Retrospective observational study investigates sicca symptoms in systemic sclerosis patients, suggesting distinct clinical characteristics.

Key Points

  • This study aims to explore the characteristics and independent factors associated with sicca symptoms in systemic sclerosis patients without Sjögren disease.
  • Conducted a single-center retrospective observational study until December 2024.
  • Excluded patients with Sjögren disease and analyzed demographic, clinical, and serological data.
  • Used multivariable logistic regression to identify predictors of sicca symptoms.
  • Out of 237 systemic sclerosis patients, 25.7% reported sicca symptoms.
  • Female sex (OR: 4.808, 95% CI: 1.088-15.308) and RV/TLC≥40% (OR: 4.413, 95% CI: 1.982-9.826) were independent predictors of sicca symptoms.
  • Sicca symptoms occurred frequently in systemic sclerosis, indicating a potential distinct clinical phenotype.

Cite This Study

Koletsos et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf488faef96ed7f056cb0https://doi.org/10.1097/rhu.0000000000002378
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