What question did this study set out to answer?

Determine the prevalence of sicca symptoms and Sjögren's syndrome according to American-European Consensus Group criteria in systemic sclerosis patients and compare their clinical and serologic profiles.

August 31, 2012International Journal of Rheumatic Diseases

The frequency of sicca symptoms and Sjögren's syndrome in patients with systemic sclerosis

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Authors

ŞKŞenol Kobak FÖFahrettin Öksel KAKenan Aksu

Discussion

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Overview

Observational study reveals high rates of Sjögren's syndrome in systemic sclerosis patients, indicating that secondary disease presentation may correlate with less severe pulmonary involvement.

Key Points

Determine the prevalence of sicca symptoms and Sjögren's syndrome according to American-European Consensus Group criteria in systemic sclerosis patients and compare their clinical and serologic profiles.
Assessed 118 patients with systemic sclerosis for sicca symptoms, ocular dryness tests (Schirmer test and tear break-up time), salivary flow, and autoantibodies (RF, ANA, anti-Ro, and anti-La).
Performed minor salivary gland biopsies on 74 patients meeting symptom, ocular/oral test, or serology criteria, defining pathology as Chisholm grade 3 or 4 sialoadenitis.
Sicca symptoms occurred in 84 of 118 patients (71.2%), and 40 of 118 patients (33.9%) met diagnostic criteria for Sjögren's syndrome based on grade 3/4 sialoadenitis.
Patients with both systemic sclerosis and Sjögren's syndrome exhibited lower rates of pulmonary hypertension and less diffuse lung disease, with significant differences in sclerodactylia (P = 0.045) and telangiectasia (P = 0.011) versus systemic sclerosis alone.
In the overlap group, 13 patients were positive for anti-Ro, 6 for anti-La, and 37 for anti-topoisomerase 1, alongside higher overall titers of rheumatoid factor, anti-nuclear antibodies, and anti-centromere antibodies.

Cite This Study

Kobak et al. (2012) studied this question.

synapsesocial.com/papers/6a7385dc20644e164b4e5f57 https://doi.org/10.1111/j.1756-185x.2012.01810.x

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August 31, 2012International Journal of Rheumatic Diseases

The frequency of sicca symptoms and Sjögren's syndrome in patients with systemic sclerosis

View Full Paper

Ask AI

Bookmark

Authors

ŞKŞenol Kobak FÖFahrettin Öksel KAKenan Aksu

Discussion

Member takes

Overview

Observational study reveals high rates of Sjögren's syndrome in systemic sclerosis patients, indicating that secondary disease presentation may correlate with less severe pulmonary involvement.

Key Points

Determine the prevalence of sicca symptoms and Sjögren's syndrome according to American-European Consensus Group criteria in systemic sclerosis patients and compare their clinical and serologic profiles.
Assessed 118 patients with systemic sclerosis for sicca symptoms, ocular dryness tests (Schirmer test and tear break-up time), salivary flow, and autoantibodies (RF, ANA, anti-Ro, and anti-La).
Performed minor salivary gland biopsies on 74 patients meeting symptom, ocular/oral test, or serology criteria, defining pathology as Chisholm grade 3 or 4 sialoadenitis.
Sicca symptoms occurred in 84 of 118 patients (71.2%), and 40 of 118 patients (33.9%) met diagnostic criteria for Sjögren's syndrome based on grade 3/4 sialoadenitis.
Patients with both systemic sclerosis and Sjögren's syndrome exhibited lower rates of pulmonary hypertension and less diffuse lung disease, with significant differences in sclerodactylia (P = 0.045) and telangiectasia (P = 0.011) versus systemic sclerosis alone.
In the overlap group, 13 patients were positive for anti-Ro, 6 for anti-La, and 37 for anti-topoisomerase 1, alongside higher overall titers of rheumatoid factor, anti-nuclear antibodies, and anti-centromere antibodies.

Cite This Study

Kobak et al. (2012) studied this question.

synapsesocial.com/papers/6a7385dc20644e164b4e5f57 https://doi.org/10.1111/j.1756-185x.2012.01810.x

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