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This study aims to evaluate early cytokine levels in COVID-19 ICU patients and their relationship with mortality.

April 15, 2026MetabolitesOpen Access

Early Cytokine Profiles in Critically Ill Patients with COVID-19 and Their Association with Mortality

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Prospective analysis associates early cytokine dynamics with mortality in critically ill COVID-19 patients, suggesting predictive potential.

This study aims to evaluate early cytokine levels in COVID-19 ICU patients and their relationship with mortality.
Prospective analytical study of ICU patients diagnosed with COVID-19.
Monitored cytokine levels from admission to three days in the ICU.
Measured circulating levels of IL-1β, IL-2, IL-6, IL-7, IL-8, IL-10, and TNF-α.
Analyzed cytokines in relation to clinical severity and 28-day mortality.
TNF-α levels increased significantly in the first 72 hours after admission.
Patients who did not survive showed higher TNF-α levels than survivors.
In multivariable analysis, TNF-α was independently associated with 28-day mortality.
Other cytokines did not maintain statistical significance regarding mortality outcomes.

Gamarra-Morales et al. (2026) studied this question.

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Prospective analysis associates early cytokine dynamics with mortality in critically ill COVID-19 patients, suggesting predictive potential.