What question did this study set out to answer?

This review aims to clarify the bidirectional crosstalk between hepatic stellate cells and the immune system in liver fibrosis.

April 15, 2026FibrosisOpen Access

Hepatic Stellate Cells Interact with the Immune System: A Bidirectional Crosstalk Network Driving Liver Fibrosis

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This review explores the interaction between hepatic stellate cells and immune cells, revealing implications for liver fibrosis development.

This review aims to clarify the bidirectional crosstalk between hepatic stellate cells and the immune system in liver fibrosis.
Reviewed existing literature on hepatic stellate cells and immune interactions.
Analyzed the role of macrophages, natural killer cells, and T cells in liver fibrosis.
Discussed mechanisms of interaction that drive liver fibrosis progression.
Highlighted the central role of immune regulatory mechanisms in activating hepatic stellate cells.
Described how interactions with immune cells maintain liver homeostasis.
Illustrated the influence of the immune microenvironment on liver fibrosis advancement.

Chu-Ning et al. (2026) studied this question.

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This review explores the interaction between hepatic stellate cells and immune cells, revealing implications for liver fibrosis development.