What question did this study set out to answer?

The study aims to identify shared transcriptional signatures across multiple carcinomas to improve early detection of malignant transformation in oral cancers.

April 15, 2026Dentistry JournalOpen Access

A Pan-Cancer Transcriptomic Signature for Conserved Molecular Programs Underlying Premalignant–Malignant Progression Across Common Carcinomas

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Authors

KKKimia Sadat KazemiUniversity of Saskatchewan MMMarta MiyazawaUniversidade Federal de Alfenas JHJoão Adolfo Costa HanemannUniversidade Federal de Alfenas

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Implication

Transcriptomic analysis identifies shared gene signatures in carcinomas, suggesting new biomarkers for early oral cancer detection.

Key Points

The study aims to identify shared transcriptional signatures across multiple carcinomas to improve early detection of malignant transformation in oral cancers.
Analyzed bulk RNA-seq data from lung, colon, breast, prostate, and head and neck cancers.
Identified differentially expressed genes with a significant log2 fold change.
Conducted functional enrichment and gene–pathway network analyses.
Examined independent premalignant and malignant datasets for early-stage relevance.
Identified a conserved 45-gene signature associated with transcriptional regulation and chromatin organization.
Regulatory hubs like ZIC5, MYBL2, and cancer-testis antigens showed significant upregulation.
Found 13 genes consistently dysregulated in early lesions across datasets.
Some genes remained altered from normal tissue to OPMD and OSCC, indicating potential as stable biomarkers.

Cite This Study

Kazemi et al. (2026) studied this question.

synapsesocial.com/papers/69df2cb9e4eeef8a2a6b1fb8 https://doi.org/10.3390/dj14040228

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A Pan-Cancer Transcriptomic Signature for Conserved Molecular Programs Underlying Premalignant–Malignant Progression Across Common Carcinomas

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Key Points

Cite This Study

A Pan-Cancer Transcriptomic Signature for Conserved Molecular Programs Underlying Premalignant–Malignant Progression Across Common Carcinomas

Discussion

Member takes

Implication

Key Points

Cite This Study

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