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July 16, 2020CancersOpen Access

Expression of MALAT1 Promotes Trastuzumab Resistance in HER2 Overexpressing Breast Cancers

Yanyuan Wu Marianna Sarkissyan Ochanya Ogah Juri Kim Jaydutt V. Vadgama

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Abstract

We show that MALAT1 contributes to HER2+ cell resistance to trastuzumab. Targeting the PI3/Akt pathway and stabilizing FOXO1 translocation could inhibit the upregulation of MALAT1.

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Wu et al. (2020) studied this question.

synapsesocial.com/papers/69df32c235659245ec6140d6 https://doi.org/10.3390/cancers12071918

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