Why the study?
Do Na+-limiting interventions during resuscitation from ventricular fibrillation prevent mitochondrial Ca2+ accumulation and attenuate myocardial injury?
Do Na+-limiting interventions during resuscitation from ventricular fibrillation prevent mitochondrial Ca2+ accumulation and attenuate myocardial injury?
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Limiting sarcolemmal Na+ entry during resuscitation from ventricular fibrillation protects against myocardial injury by preventing mitochondrial Ca2+ overload in a preclinical model.
Na+ -limiting interventions prevented excess Ca2+ m accumulation induced by ischemia and reperfusion and ameliorated myocardial injury and dysfunction.
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Wang et al. (2007) studied this question.
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