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August 15, 1996Journal of Clinical InvestigationOpen Access

Role of aldosterone in the remnant kidney model in the rat.

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Why the study?

Does aldosterone contribute to hypertension and renal injury in the remnant kidney model in rats?

Population

Rats with remnant kidney model (REM) and SHAM-operated rats

Comparison

Losartan and enalapril with or without exogenous… vs Untreated remnant rats and SHAM-operated rats

Design

Preclinical

Follow-up

4 weeks

Authors

EGEddie L. GreeneMayo ClinicSKStefan M. KrenUniversity of MinnesotaTHThomas H. HostetterUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Aldosterone may drive residual renal injury despite RAAS blockade in rat remnant kidney; leaves open translation to human CKD therapies.

Structured PICO

Does aldosterone contribute to hypertension and renal injury in the remnant kidney model in rats?

P
Population
Rats with remnant kidney model (REM) and SHAM-operated rats
I
Intervention
Losartan and enalapril with or without exogenous aldosterone infusion; spironolactone
C
Comparator
Untreated remnant rats (REM) and SHAM-operated rats
O
Outcome
Proteinuria, hypertension, and glomerulosclerosissurrogate

Aldosterone contributes significantly to hypertension and renal injury in the remnant kidney model in rats.

Cite This Study

Greene et al. (1996) studied this question.

synapsesocial.com/papers/69df3c34acbf09c32e614649https://doi.org/10.1172/jci118867
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Also Consider

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  1. 1Mineralocorticoids, hypertension, and cardiac fibrosis.1994 · 439 citations
  2. 2Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass.1992 · 348 citations
  3. 3Adverse effects of growth in the glomerular microcirculation1990 · 99 citations
  4. 4Hypertension-Related Renal Injury: A Major Contributor to End-Stage Renal Disease1993 · 106 citations
  5. 5Mechanisms by which nephrectomy stimulates adrenal renin.1986 · 45 citations