What question did this study set out to answer?

Determine whether DNA methylation levels fluctuate over time within individuals and whether the maintenance of methylation patterns displays familial clustering.

June 24, 2008JAMA

Intra-individual Change Over Time in DNA Methylation With Familial Clustering

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Authors

HBHans T. BjörnssonJohns Hopkins University

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Implication

Longitudinal family study shows intra-individual changes in DNA methylation over time, suggesting epigenetic maintenance is under genetic control.

Key Points

Determine whether DNA methylation levels fluctuate over time within individuals and whether the maintenance of methylation patterns displays familial clustering.
Tracked longitudinal intra-individual variations in DNA methylation status across time.
Evaluated methylation maintenance dynamics across family groups to detect evidence of genetic regulation.
DNA methylation levels shifted within individuals over time.
Methylation maintenance exhibited familial clustering, indicating underlying genetic control over temporal epigenetic changes.

Cite This Study

Hans T. Björnsson (2008) studied this question.

synapsesocial.com/papers/69df3f1d35659245ec6145d2 https://doi.org/10.1001/jama.299.24.2877

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Implication

Longitudinal family study shows intra-individual changes in DNA methylation over time, suggesting epigenetic maintenance is under genetic control.

Intra-individual Change Over Time in DNA Methylation With Familial Clustering

Discussion

Member takes

Implication

Key Points

Cite This Study

Intra-individual Change Over Time in DNA Methylation With Familial Clustering

Discussion

Member takes

Implication

Key Points

Cite This Study

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