Does single-pill antihypertensive combination therapy reduce cardiovascular events and all-cause mortality compared to identical drugs as multipills in hypertensive patients?
Single-pill combination therapy for hypertension improves medication persistence and reduces mortality and cardiovascular events compared to multipill regimens, supporting current guideline recommendations.
Antihypertensive combination therapy reduces all-cause mortality and cardiovascular events when provided as single pill compared to identical drugs as multipills. This strongly supports the European Society of Cardiology/European Society of Hypertension and International Society of Hypertension guidelines recommending the use of a single-pill combination and thus should be more rigorously implemented into daily clinical practice.
Schmieder et al. (Wed,) studied this question.