Why the study?
Does chlorthalidone stepped-care therapy improve life expectancy in patients with isolated systolic hypertension?
Does chlorthalidone stepped-care therapy improve life expectancy in patients with isolated systolic hypertension?
Short-term treatment (4.5 years) of isolated systolic hypertension with chlorthalidone is associated with a long-term survival benefit at 22 years.
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May support lasting survival gains from short-term chlorthalidone in isolated systolic hypertension; leaves open need for randomized confirmation.
Kostis et al. (2011) studied this question.
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