Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype

Brunangelo Falini; Cristina Mecucci; Enrico Tiacci; Myriam Alcalay; Roberto Rosati; Laura Pasqualucci; Roberta La Starza; Daniela Diverio; Emanuela Colombo; Antonella Santucci; Barbara Bigerna; Roberta Pacini; Alessandra Pucciarini; Arcangelo Liso; Marco Vignetti; Paola Fazi; Natalia Meani; Valentina Pettirossi; Giuseppe Saglio; Franco Mandelli; Francesco Lo‐Coco; Pier Giuseppe Pelicci; Maria Paola Martelli

doi:10.1056/nejmoa041974

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Abstract

Cytoplasmic NPM is a characteristic feature of a large subgroup of patients with AML who have a normal karyotype, NPM gene mutations, and responsiveness to induction chemotherapy.

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Falini et al. (2005) studied this question.

synapsesocial.com/papers/69df449ec51a1f47d47a0f96 https://doi.org/10.1056/nejmoa041974

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Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype

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Abstract

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Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype

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