Tumor Genomic Profile Is Associated With Arterial Thromboembolism Risk in Patients With Solid Cancer

Figures

• 

  Figure 1. 1-Year Cumulative Incidence of Arterial Thromboembolism by Tumor Type Arterial thromboembolism is defined as a composite of myocardial infarction, coronary revascularization, ischemic stroke, peripheral arterial occlusion, and limb revascularization. The “other” category comprises all solid tumors not included in any other specific category. Death was considered a competing event when estimating the cumulative incidence. Each dot represents the 1-year point estimate, and the corresponding lines are the 95% CIs.

• 

  Figure 2. 1-Year Cumulative Incidence of ATE According to Alteration Type Arterial thromboembolism (ATE) is defined as a composite of myocardial infarction, coronary revascularization, ischemic stroke, peripheral arterial occlusion, and limb revascularization. Death was considered a competing event when estimating the cumulative incidence. Plots are shown for the unadjusted 1-year cumulative incidences of ATE for individuals with vs without somatic alterations in KRAS and STK11. Data are reported for patients with lung cancer, colorectal cancer, and other. The “other” cancer category comprises all solid tumors not included in any other specific category.

• 

  Central Illustration. Solid Tumor Genomic Alterations Are Associated With Arterial Thromboembolism Risk Electronic medical record notes were assessed for 11,871 adult cancer patients from the Memorial Sloan Kettering–Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) cohort. Notes were processed and searched for keywords indicative of an arterial thromboembolic event, defined as a composite of myocardial infarction, coronary revascularization, ischemic stroke, peripheral arterial occlusion, and limb revascularization. All detected events were confirmed by a subject matter expert. The effect of somatic genomic alterations in select oncogenes and tumor suppressor genes on the risk for arterial thromboembolism was assessed, adjusting for pertinent covariates. Modified from Dunbar et al.20 MI = myocardial infarction; NLP = natural language processing.