What question did this study set out to answer?

To determine whether an immunohistochemical antibody panel can reliably distinguish myofibroblastic proliferations from smooth muscle lesions in skin and soft tissue.

April 1, 2006American Journal of Dermatopathology

Differential Expression of Smooth Muscle Myosin, Smooth Muscle Actin, H-Caldesmon, and Calponin in the Diagnosis of Myofibroblastic and Smooth Muscle Lesions of Skin and Soft Tissue

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Authors

DPDelia Pérez‐MontielSecretaria de Salud JPJose A. PlazaColumbia University Irving Medical Center HDHugo Domínguez‐MalagónUniversity of Miami

Discussion

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Implication

Histopathologic study demonstrates divergent antibody profiles in cutaneous spindle cell lesions, highlighting reliable markers for distinguishing myofibroblastic and smooth muscle tumors.

Key Points

To determine whether an immunohistochemical antibody panel can reliably distinguish myofibroblastic proliferations from smooth muscle lesions in skin and soft tissue.
Stained 73 myofibroblastic lesions (28 nodular fasciitis, 42 fibromatosis, 3 myofibroblastic sarcomas) and 20 smooth muscle tumors (12 cutaneous leiomyomas, 8 leiomyosarcomas).
Evaluated immunohistochemical expression across all specimens using antibodies against smooth muscle actin (SMA), smooth muscle myosin (SMMS), calponin, and high-molecular-weight caldesmon (h-caldesmon).
Myofibroblastic lesions showed frequent positivity for SMA (28/28 nodular fasciitis, 38/42 fibromatosis, 3/3 sarcomas) and calponin (28/28 nodular fasciitis, 42/42 fibromatosis, 2/3 sarcomas), but lacked SMMS (negative in 28/28, 39/42, and 3/3) and were entirely negative for h-caldesmon (0/73).
Smooth muscle tumors exhibited uniform reactivity across all tested markers, with 100% of cutaneous leiomyomas (12/12) and leiomyosarcomas (8/8) staining positive for SMA, SMMS, calponin, and h-caldesmon.

Cite This Study

Pérez‐Montiel et al. (2006) studied this question.

synapsesocial.com/papers/69df4be8d5404a0bea592d9f https://doi.org/10.1097/01.dad.0000200009.02939.cc

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Implication

Histopathologic study demonstrates divergent antibody profiles in cutaneous spindle cell lesions, highlighting reliable markers for distinguishing myofibroblastic and smooth muscle tumors.

Differential Expression of Smooth Muscle Myosin, Smooth Muscle Actin, H-Caldesmon, and Calponin in the Diagnosis of Myofibroblastic and Smooth Muscle Lesions of Skin and Soft Tissue

Discussion

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Implication

Key Points

Cite This Study

Differential Expression of Smooth Muscle Myosin, Smooth Muscle Actin, H-Caldesmon, and Calponin in the Diagnosis of Myofibroblastic and Smooth Muscle Lesions of Skin and Soft Tissue

Discussion

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Implication

Key Points

Cite This Study

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