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April 30, 2003New England Journal of MedicineOpen Access

Decline in Invasive Pneumococcal Disease after the Introduction of Protein–Polysaccharide Conjugate Vaccine

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Authors

CWCynthia G. WhitneyEmory UniversityMFMonica M. FarleyUniversity of North Carolina at Chapel HillJHJames L. HadlerAT&T (United States)

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Overview

Population surveillance demonstrates decreased invasive pneumococcal disease in young children and adults, suggesting effective control of drug-resistant strains.

Key Points

  • To evaluate the impact of introducing the protein–polysaccharide pneumococcal conjugate vaccine on rates of invasive pneumococcal disease in children and adults.
  • Assessed population-level trends in invasive pneumococcal disease following conjugate vaccine implementation.
  • Tracked infection frequencies in vaccinated pediatric groups and unvaccinated adult populations.
  • Monitored changes in disease incidence attributable to drug-resistant bacterial strains.
  • Invasive pneumococcal disease was substantially prevented among young children targeted by vaccination.
  • Infection rates also declined among adult populations despite not receiving direct vaccination.
  • Disease burden associated with drug-resistant pneumococcal strains decreased following vaccine deployment.

Cite This Study

Whitney et al. (2003) studied this question.

synapsesocial.com/papers/69df4f904fb243fc8e591ef1https://doi.org/10.1056/nejmoa022823
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