Why the study?
What is the relationship between renal function and serum sclerostin levels in adult patients with CKD?
What is the relationship between renal function and serum sclerostin levels in adult patients with CKD?
Elevated serum sclerostin in CKD is associated with GFR, sex, and serum phosphate, suggesting that previously reported age effects may actually be due to altered renal function.
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Sclerostin levels require GFR adjustment in CKD interpretation; leaves open independent prognostic value beyond phosphate and sex.
This is the first study reporting higher serum sclerostin levels starting at CKD stage III. GFR, sex, and serum phosphate were the only measures associated with sclerostin level, suggesting that the effect of age reported in the literature might instead be attributable to the altered renal function in the elderly. Correcting the serum phosphorus level may be associated with lower sclerostin levels.
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Pelletier et al. (2013) studied this question.
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