Why the study?
Do selective COX-2 inhibitors increase the risk of cardiovascular events such as myocardial infarction and stroke?
Do selective COX-2 inhibitors increase the risk of cardiovascular events such as myocardial infarction and stroke?
This review highlights the biological plausibility and clinical evidence that selective COX-2 inhibitors increase the risk of myocardial infarction and stroke by removing the protective constraint of COX-2-derived PGI2.
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Caution advised with selective COX-2 inhibitors in CV-risk patients; leaves open optimal agent selection and duration effects.
Tilo Großer (2005) studied this question.
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