What question did this study set out to answer?

Investigate how Akebia saponin D regulates microglial function and restores adult hippocampal neurogenesis in a mouse model of chronic mild stress.

March 29, 2023CNS Neuroscience & TherapeuticsOpen Access

Akebia saponin D acts via the PPAR ‐gamma pathway to reprogramme a pro‐neurogenic microglia that can restore hippocampal neurogenesis in mice exposed to chronic mild stress

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Investigate how Akebia saponin D regulates microglial function and restores adult hippocampal neurogenesis in a mouse model of chronic mild stress.
Evaluated mice subjected to chronic mild stress (CMS) protocols.
Administered Akebia saponin D (ASD) and assessed PPAR-γ pathway activation.
Examined microglial phenotypes, BDNF expression, and neural stem/progenitor cell (NSPC) proliferation, survival, and neurogenesis in the dentate gyrus.
ASD reprogrammed microglia toward a pro-neurogenic phenotype in the dentate gyrus via PPAR-γ activation.
Treatment increased brain-derived neurotrophic factor (BDNF) expression in the hippocampus.
Microglial modulation led to restored neural stem and progenitor cell proliferation, enhanced survival, and stimulated neurogenesis under chronic stress conditions.

Implication

Animal study reveals Akebia saponin D restores neurogenesis via microglial reprogramming in stressed mice, suggesting potential therapeutic value for stress-related mood disorders.

Abstract

These results suggested that ASD acts via the PPAR-γ pathway to induce a pro-neurogenic microglia in dentate gyrus of CMS mice that can increase BDNF expression and promote NSPC proliferation, survival, and neurogenesis.

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Cite This Study

Zhang et al. (2023) studied this question.

synapsesocial.com/papers/69df6e54d5404a0bea5931cf https://doi.org/10.1111/cns.14196

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Implication

Animal study reveals Akebia saponin D restores neurogenesis via microglial reprogramming in stressed mice, suggesting potential therapeutic value for stress-related mood disorders.

Akebia saponin D acts via the PPAR ‐gamma pathway to reprogramme a pro‐neurogenic microglia that can restore hippocampal neurogenesis in mice exposed to chronic mild stress

Key Points

Implication

Abstract

Discussion

Cite This Study

Akebia saponin D acts via the PPAR ‐gamma pathway to reprogramme a pro‐neurogenic microglia that can restore hippocampal neurogenesis in mice exposed to chronic mild stress

Key Points

Implication

Abstract

Discussion

Cite This Study

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