Why the study?
Does cardiopulmonary failure in children with Enterovirus 71 infection and CNS involvement affect neurodevelopment and cognitive functioning?
Does cardiopulmonary failure in children with Enterovirus 71 infection and CNS involvement affect neurodevelopment and cognitive functioning?
Children with Enterovirus 71 infection and CNS involvement who develop cardiopulmonary failure are at risk for delayed neurodevelopment and reduced cognitive functioning.
Suggests neurodevelopmental monitoring for EV71 cases with cardiopulmonary failure; leaves open causal links and intervention effects in observational data.
Enterovirus 71 infection with CNS involvement and cardiopulmonary failure may be associated with neurologic sequelae, delayed neurodevelopment, and reduced cognitive functioning. Children with CNS involvement without cardiopulmonary failure did well on neurodevelopment tests. (ClinicalTrials.gov number, NCT00172393 [ClinicalTrials.gov].).
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Chang et al. (2007) studied this question.
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