What question did this study set out to answer?

To determine whether interleukin-17 receptor signaling is required for granulocyte colony-stimulating factor production, CXC chemokine expression, and pulmonary host defense against bacterial infection.

August 20, 2001The Journal of Experimental MedicineOpen Access

Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense

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Authors

PYPeng YeArmy Medical University FRFred H. RodriguezAdult Congenital Heart Disease SKSuzanne T. KanalyUniversity of Iowa

Discussion

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Implication

Murine study reveals critical role of interleukin 17 receptor signaling in pulmonary defense against bacteria, highlighting mechanisms predisposing CD4-deficient hosts to pneumonia.

Key Points

To determine whether interleukin-17 receptor signaling is required for granulocyte colony-stimulating factor production, CXC chemokine expression, and pulmonary host defense against bacterial infection.
Inoculated mice genetically deficient in interleukin-17 receptor (IL-17R KO) or overexpressing soluble IL-17R with intranasal Klebsiella pneumoniae.
Measured survival, bacterial dissemination, alveolar neutrophil recruitment, and lung expression of G-CSF and MIP-2 mRNA and protein.
IL-17R knockout mice experienced 100% mortality within 48 hours compared to 40% mortality in control mice.
IL-17R-deficient mice exhibited delayed neutrophil recruitment into alveolar spaces alongside increased systemic dissemination of K. pneumoniae.
Lungs of IL-17R knockout mice showed significant reductions in steady-state mRNA and protein levels of G-CSF and MIP-2 following bacterial challenge.

Cite This Study

Ye et al. (2001) studied this question.

synapsesocial.com/papers/69df80bd6324afb55d592bd8 https://doi.org/10.1084/jem.194.4.519

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August 20, 2001The Journal of Experimental MedicineOpen Access

Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense

View Full Paper

Ask AI

Bookmark

Authors

PYPeng YeArmy Medical University FRFred H. RodriguezAdult Congenital Heart Disease SKSuzanne T. KanalyUniversity of Iowa

Discussion

Member takes

Implication

Murine study reveals critical role of interleukin 17 receptor signaling in pulmonary defense against bacteria, highlighting mechanisms predisposing CD4-deficient hosts to pneumonia.

Key Points

To determine whether interleukin-17 receptor signaling is required for granulocyte colony-stimulating factor production, CXC chemokine expression, and pulmonary host defense against bacterial infection.
Inoculated mice genetically deficient in interleukin-17 receptor (IL-17R KO) or overexpressing soluble IL-17R with intranasal Klebsiella pneumoniae.
Measured survival, bacterial dissemination, alveolar neutrophil recruitment, and lung expression of G-CSF and MIP-2 mRNA and protein.
IL-17R knockout mice experienced 100% mortality within 48 hours compared to 40% mortality in control mice.
IL-17R-deficient mice exhibited delayed neutrophil recruitment into alveolar spaces alongside increased systemic dissemination of K. pneumoniae.
Lungs of IL-17R knockout mice showed significant reductions in steady-state mRNA and protein levels of G-CSF and MIP-2 following bacterial challenge.

Cite This Study

Ye et al. (2001) studied this question.

synapsesocial.com/papers/69df80bd6324afb55d592bd8 https://doi.org/10.1084/jem.194.4.519

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