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Summarize recent advances in the biogenesis, metabolism, and functions of circular RNAs, focusing on the molecular mechanisms governing circRNA-protein interactions and their clinical utility.

December 1, 2020Molecular CancerOpen Access

Circular RNA: metabolism, functions and interactions with proteins

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Summarize recent advances in the biogenesis, metabolism, and functions of circular RNAs, focusing on the molecular mechanisms governing circRNA-protein interactions and their clinical utility.
Narrative review synthesizing published literature on circular RNA (circRNA) biogenesis, regulation, cellular localization, and degradation.
Evaluation of molecular mechanisms mediating circRNA-protein interactions, including protein scaffolding, sequestering, and translocation across biological systems.
Identifies circRNA functions as transcriptional regulators, microRNA sponges, translational templates, and versatile protein interactors that direct scaffolding, tethering, and chromatin recruitment.
Highlights distinct circRNA expression signatures linked to disease states, supporting their utility as non-invasive diagnostic biomarkers and therapeutic targets in translational medicine.

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Implication

Review uncovers diverse regulatory mechanisms and protein interactions of circular RNA across species, highlighting their potential as diagnostic biomarkers and therapeutic targets.

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Zhou et al. (2020) studied this question.

synapsesocial.com/papers/69dfed71915fa04953615187 https://doi.org/10.1186/s12943-020-01286-3

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Implication

Review uncovers diverse regulatory mechanisms and protein interactions of circular RNA across species, highlighting their potential as diagnostic biomarkers and therapeutic targets.

Circular RNA: metabolism, functions and interactions with proteins

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Discussion

Implication

Cite This Study

Circular RNA: metabolism, functions and interactions with proteins

Key Points

Discussion

Implication

Cite This Study

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