Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 29, 2020New England Journal of MedicineOpen Access

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does the 100-μg dose of the SARS-CoV-2 mRNA-1273 vaccine improve immunogenicity compared to the 25-μg dose in older adults?

Population

Older adults

Comparison

100-μg dose vs 25-μg dose of mRNA-1273 vaccine

Authors

EAEvan J. AndersonEmory UniversityNRNadine RouphaelEmory UniversityAWAlicia T. WidgeNational Institute of Allergy and Infectious Diseases

Discussion

Loading...

Member takes

Overview

Supports 100-μg dosing for phase 3 trials in older adults; extends dose-finding data for mRNA-1273.

Structured PICO

Does the 100-μg dose of the SARS-CoV-2 mRNA-1273 vaccine improve immunogenicity compared to the 25-μg dose in older adults?

P
Population
Older adults
I
Intervention
SARS-CoV-2 mRNA-1273 vaccine 100-μg dose
C
Comparator
SARS-CoV-2 mRNA-1273 vaccine 25-μg dose
O
Outcome
Safety (adverse events) and immunogenicity (binding- and neutralizing-antibody titers)safety

The 100-μg dose of the mRNA-1273 vaccine is safe and more immunogenic than the 25-μg dose in older adults, supporting its use in phase 3 trials.

Cite This Study

Anderson et al. (2020) studied this question.

synapsesocial.com/papers/69dfee26032653edbf7a0e2ahttps://doi.org/10.1056/nejmoa2028436
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Disappearance of Antibodies to SARS-Associated Coronavirus after Recovery2007 · 421 citations
  2. 2Varicella‐Zoster Virus–Specific Immune Responses in Elderly Recipients of a Herpes Zoster Vaccine2008 · 356 citations
  3. 3Immune Senescence and Vaccination in the Elderly2013 · 57 citations
  4. 4Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen2017 · 1,243 citations
  5. 5The Importance of Frailty in the Assessment of Influenza Vaccine Effectiveness Against Influenza-Related Hospitalization in Elderly People2017 · 174 citations