New Sandwich‐Type Enzyme‐Linked Immunosorbent Assay for Human MxA Protein in a Whole Blood Using Monoclonal Antibodies Against GTP‐Binding Domain for Recognition of Viral Infection

Mizuho Kawamura; Akira Kusano; Akiko Furuya; Nobuo Hanai; Hideki Tanigaki; Akihito Tomita; Akira Horiguchi; Kyosuke Nagata; Toshiko Itazawa; Yuichi Adachi; Yoshie Okabe; Toshio Miyawaki; Hiroaki Kohno

doi:10.1002/jcla.21507

May 1, 2012Journal of Clinical Laboratory Analysis

New Sandwich‐Type Enzyme‐Linked Immunosorbent Assay for Human MxA Protein in a Whole Blood Using Monoclonal Antibodies Against GTP‐Binding Domain for Recognition of Viral Infection

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Why the study?

Can a new sandwich-type ELISA for MxA protein accurately detect viral infection in human whole blood?

Structured PICO

Can a new sandwich-type ELISA for MxA protein accurately detect viral infection in human whole blood?

P

Population

Human whole blood samples

I

Intervention

New sandwich-type enzyme-linked immunosorbent assay (ELISA) for measuring MxA protein using monoclonal antibodies against the GTP-binding domain

O

Outcome

Analytical performance for routine clinical assay and detection of viral infectionsurrogate

A newly developed ELISA for MxA protein shows promise as a routine clinical assay for detecting viral infections.

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Implication

Supports MxA ELISA development for viral detection; leaves open clinical utility pending prospective validation.

Abstract

We have developed a new ELISA for measuring MxA protein in human whole blood using mAbs specific for the GTP-binding domain of MxA. This ELISA has analytical performance enough for routine clinical assay and can be used in detecting the possibility of viral infection.

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Cite This Study

Kawamura et al. (2012) studied this question.

synapsesocial.com/papers/69dfefe093e101b251e9be9a https://doi.org/10.1002/jcla.21507

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New Sandwich‐Type Enzyme‐Linked Immunosorbent Assay for Human MxA Protein in a Whole Blood Using Monoclonal Antibodies Against GTP‐Binding Domain for Recognition of Viral Infection

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

New Sandwich‐Type Enzyme‐Linked Immunosorbent Assay for Human MxA Protein in a Whole Blood Using Monoclonal Antibodies Against GTP‐Binding Domain for Recognition of Viral Infection

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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