Potential Role of 18fluorodeoxyglucose–positron Emission Tomography/Computed Tomography in Differentiating Benign Neurofibroma From Malignant Peripheral Nerve Sheath Tumor Associated With Neurofibromatosis 1

This study, on a limited number of cases, demonstrates the potential use of 18FDG-PET/CT to augment management of PNfibs, especially in the context of neurofibromatosis type 1, which is characterized by multiple tumors. The addition of CT anatomic imaging to 18FGD-PET can facilitate targeting biopsies to metabolic hot spots, to further augment diagnostic sensitivity. Much larger numbers of MPNSTs, which can only be accrued in a collaborative manner among institutions, are required to further assess the specificity and sensitivity of 18FDG-PET/CT in the diagnosis of MPNSTs.