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July 5, 2008Endocrine Related CancerOpen Access

Prognostic factors of long-term outcome in gastroenteropancreatic neuroendocrine tumours

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Authors

UPU.-F. PapeUBUta BerndtJMJacqueline Müller‐Nordhorn

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Overview

Retrospective cohort study reveals key prognostic survival factors in gastroenteropancreatic neuroendocrine tumors, highlighting parameters for clinical risk stratification.

Key Points

  • Identify clinically accessible prognostic factors and evaluate long-term survival outcomes in patients with gastroenteropancreatic neuroendocrine tumours.
  • Analyzed clinical, epidemiological, and histopathological records in a single-centre retrospective cohort of 399 patients with histologically confirmed neuroendocrine tumours.
  • Assessed survival distributions using the Kaplan-Meier method, log-rank testing, and multivariate Cox regression modeling.
  • Overall 5- and 10-year survival rates reached 78% and 63% respectively, while 69.4% of patients presented with distant metastases at initial diagnosis, most commonly in the liver (85%).
  • Time to progression after diagnosis occurred significantly earlier in patients with pancreatic primary tumours compared to ileal tumours.
  • Multivariate analysis confirmed that primary tumour diameter under 25 mm, absence of metastases, lack of clinical symptoms, positive chromogranin A expression, and a lower Ki67 index were independent predictors of favorable survival.

Cite This Study

Pape et al. (2008) studied this question.

synapsesocial.com/papers/69dff53993e101b251e9c100https://doi.org/10.1677/erc-08-0017
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