May 3, 2014Journal of Biochemical and Molecular Toxicology

Modulator Effects of Meloxicam against Doxorubicin-Induced Nephrotoxicity in Mice

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Why the study?

Does meloxicam prevent doxorubicin-induced nephrotoxicity in mice?

Structured PICO

Does meloxicam prevent doxorubicin-induced nephrotoxicity in mice?

Population

40 male mice

Intervention

Meloxicam (daily) administered with doxorubicin (twice/week) for 2 weeks

Comparator

Saline, meloxicam alone, or doxorubicin alone

Outcome

Renal injury parameters including relative kidney weight, lipid peroxidation, inflammatory cytokines (IL-6, TNF-α), caspase-3 activity, PGE2 content, histology, renal function tests, and antioxidant enzyme activitiessurrogate

Meloxicam may protect against doxorubicin-induced nephrotoxicity by reducing inflammation and oxidative stress in a mouse model.

Discussion

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Implication

Meloxicam may protect against doxorubicin nephrotoxicity in mice; hypothesis-generating and should not change practice.

Cite This Study

Hassan et al. (2014) studied this question.

synapsesocial.com/papers/69dff587ca6b6a2615860505 https://doi.org/10.1002/jbt.21570

Topics

Bremelanotide

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Modulator Effects of Meloxicam against Doxorubicin-Induced Nephrotoxicity in Mice

Structured PICO

Discussion

Implication

Cite This Study

Topics

Modulator Effects of Meloxicam against Doxorubicin-Induced Nephrotoxicity in Mice

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider