TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

Laura Flinn; Marcus Keatinge; Sandrine Bretaud; Heather Mortiboys; Hideaki Matsui; Elena De Felice; Helen I. Woodroof; Lucy Brown; Aimee McTighe; Rosemarie Soellner; Claire Allen; Paul R. Heath; Marta Milo; Miratul M. K. Muqit; Andreas S. Reichert; Reinhard W. Köster; Philip W. Ingham; Oliver Bandmann

doi:10.1002/ana.23999

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Abstract

Pink1(-/-) zebrafish are the first vertebrate model of PINK1 deficiency with loss of dopaminergic neurons. Our study also identifies TIGAR as a promising novel target for disease-modifying therapy in PINK1-related PD.

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Flinn et al. (2013) studied this question.

synapsesocial.com/papers/69dff59e93e101b251e9c192 https://doi.org/10.1002/ana.23999

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TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

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TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

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