Why the study?
Is IGFBP-2 associated with bone mineral density in aging men and women?
Is IGFBP-2 associated with bone mineral density in aging men and women?
IGFBP-2 is identified as a negative predictor of bone mineral density in aging adults, suggesting a deleterious role in age-related bone loss.
Should not yet change clinical BMD assessment; leaves open IGFBP-2 as a modifiable target in age-related bone loss.
Among the IGF/IGFBPs in our study, IGFBP-2 was a key negative predictor of BMD among men and women, particularly postmenopausal women. Our findings suggest a potential role of the IGF/IGFBP system in regulating bone loss in aging men and women and identify a previously under-recognized, potentially deleterious role for IGFBP-2, a known inhibitor of IGF action that increases with age in both sexes. Whether the action of the IGF/IGFBP system on bone metabolism is mediated partly through its effects on muscle mass or SHBG deserves further study.
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Amin et al. (2004) studied this question.
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