Why the study?
Are circulating irisin levels associated with endothelial dysfunction in nonhypertensive, nondiabetic obese subjects?
Are circulating irisin levels associated with endothelial dysfunction in nonhypertensive, nondiabetic obese subjects?
Lower circulating irisin levels are associated with endothelial dysfunction in obesity, suggesting a potential regulatory role for irisin in vascular health.
Irisin measurement should not guide endothelial assessment in obese patients yet; hypothesis-generating for its role in obesity-related vascular dysfunction.
Circulating irisin level was decreased in nonhypertensive, nondiabetic obese subjects compared with lean healthy control. Lower levels of irisin are independently associated with endothelial dysfunction. Therefore, irisin may be involved in the regulation of endothelial function in obesity.
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Hou et al. (2014) studied this question.
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