Why the study?
In chronic heart failure, some parameters of oxidative stress correlate with disease severity, but their role in prognostic risk stratification required evaluation.
Do elevated serum malondialdehyde and uric acid concentrations predict death or heart transplantation in patients with chronic HFrEF?
Population
774 patients aged 48-59 years with chronic HF with reduced ejection fraction
Comparison
Biomarkers of oxidative stress evaluated across levels or quartiles
Design
Observational cohort study
Follow-up
1-year
Authors
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Higher MDA was associated with mortality risk in chronic HFrEF; hypothesis-generating for oxidative biomarkers, needs prospective validation.
Do elevated serum malondialdehyde and uric acid concentrations predict death or heart transplantation in patients with chronic HFrEF?
Elevated serum malondialdehyde and uric acid concentrations are independent predictors of 1-year mortality and heart transplantation in patients with chronic HFrEF.
Romuk et al. (2019) studied this question.
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