Triglyceride-Glucose Index and Homeostasis Model Assessment-Insulin Resistance in Young Adulthood and Risk of Incident Congestive Heart Failure in Midlife: The Coronary Artery Risk Development in Young Adults Study

FIGURE 1. The association between the TyG index and HOMA-IR. The association between the TyG index and HOMA-IR. (A) Each black point represents a sample. (B) A solid black line represents the smooth curve fit between variables. The gray area represents the 95% of confidence interval (CI) from the fit. Abbreviations: TyG, Triglyceride-glucose; HOMA-IR, homeostasis model assessment-insulin resistance.

FIGURE 2. Kaplan–Meier curves for incidence of CHF stratified by quartiles of TyG index (A) and HOMA-IR (B). Abbreviations: TyG, Triglyceride-glucose; HOMA-IR, homeostasis model assessment-insulin resistance; CHF, congestive heart failure.

FIGURE 3. The association of CHF and the TyG index by a subgroup analysis. The association of CHF and the TyG index by a sub-group analysis. Data are hazard ratios (HRs) and 95% confidence limits (95% CLs). The participants were divided into subgroups according to sex, race, education, obesity, smoking status, hypertension, and CKD. The results were evaluated after adjusted for age, sex, race, education, obesity, smoking status, hypertension, diabetes mellitus, hypercholesteremia, CKD, LDL-C, and HDL-C except for the sub-group variable. Abbreviations: HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TyG, Triglyceride-glucose; CKD, chronic kidney diseases; HOMA-IR, homeostasis model assessment-insulin resistance; CHF, congestive heart failure.

FIGURE 4. An ROC analysis of the TyG index and HOMA-IR to predict the incident risk of CHF. A solid blue line represents the TyG index; a solid red line represents HOMA-IR. Abbreviations: ROC, receiver operating characteristic; AUC, area under the curve; TyG, Triglyceride-glucose; HOMA-IR, homeostasis model assessment-insulin resistance; CHF, congestive heart failure.