Does lowering diastolic blood pressure to less than 60 mm Hg increase the risk of cardiovascular events in adults with high cardiovascular risk and treated systolic blood pressure less than 130 mm Hg?
In high-risk patients with treated SBP <130 mm Hg, a DBP <60 mm Hg is associated with increased cardiovascular events, suggesting an optimal DBP target of 70-80 mm Hg.
This cohort study found that lowering diastolic blood pressure to less than 60 mm Hg was associated with increased risk of cardiovascular events in patients with high cardiovascular risk and an treated systolic blood pressure less than 130 mm Hg. The finding that a diastolic blood pressure value between 70 and 80 mm Hg was an optimum target for this patient population merits further study.
Li et al. (Wed,) studied this question.