What question did this study set out to answer?

Synthesize current evidence on the mechanistic pathways linking gut microbiota, intestinal barrier function, and low-grade inflammation in obesity and type 2 diabetes.

February 1, 2013Best Practice & Research Clinical GastroenterologyOpen Access

Diabetes, obesity and gut microbiota

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Synthesize current evidence on the mechanistic pathways linking gut microbiota, intestinal barrier function, and low-grade inflammation in obesity and type 2 diabetes.
Literature review evaluating mechanistic pathways linking gut microbial composition, intestinal barrier integrity, and metabolic endotoxemia.
Evaluation of preclinical and human studies examining prebiotic non-digestible carbohydrates as metabolic interventions.
Gut barrier dysfunction driven by microbial alterations promotes metabolic endotoxemia and systemic low-grade inflammation in metabolic disorders.
Enteroendocrine cells and the endocannabinoid system regulate gut permeability and inflammatory responses associated with metabolic disease.
Prebiotic non-digestible carbohydrates improve metabolic markers in preclinical models, identifying the gut microbiota as a viable therapeutic target.

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Implication

Review uncovers mechanisms linking gut barrier dysfunction to metabolic disorders in obesity and diabetes, highlighting the therapeutic potential of targeting gut microbes.

Cite This Study

Everard et al. (2013) studied this question.

synapsesocial.com/papers/69e005ba1827a1d0b1255e44 https://doi.org/10.1016/j.bpg.2013.03.007

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Implication

Review uncovers mechanisms linking gut barrier dysfunction to metabolic disorders in obesity and diabetes, highlighting the therapeutic potential of targeting gut microbes.

Diabetes, obesity and gut microbiota

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Diabetes, obesity and gut microbiota

Key Points

Discussion

Implication

Cite This Study

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