UCP2 acts as a mechanosensitive suppressor of atherosclerosis, suggesting that enhancing its levels could be a novel therapeutic strategy.
Altogether, our studies uncover that UCP2 is novel mechanosensitive gene under the control of fluid shear stress and KLF2 in ECs. UCP2 expression is critical for endothelial proinflammatory response and atherogenesis. Therapeutic strategies enhancing UCP2 level may have therapeutic potential against atherosclerosis.
Luo et al. (Thu,) studied this question.
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