Key result
Impaired fibrillin-1 function drives vascular stiffness and promotes multifocal plaque instability in mice.
Population
Apolipoprotein E-deficient mice
Design
Preclinical
Authors
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Does not alter clinical practice; hypothesis-generating for elastic fiber-targeted therapies in atherosclerosis.
Impaired fibrillin-1 function and elastic fiber fragmentation increase vascular stiffness and promote plaque instability in an ApoE-deficient mouse model.
Herck et al. (2009) studied this question. Impaired fibrillin-1 function and elastic fiber fragmentation increase vascular stiffness, promoting features of multifocal plaque instability in apolipoprotein E-deficient mice.
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