Preclinical study demonstrates that moderate environmental enrichment reduces white matter glial activation in chronic hypoperfusion, suggesting therapeutic value in vascular dementia.
Our results suggest that moderate or limited exposure to EE substantially reduced glial damage/activation. Our findings also suggest moderate rather than continuous exposure to EE is beneficial for patients with subcortical ischaemic vascular dementia characterised by white matter disease-related inflammation.
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Hase et al. (2017) studied this question.
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