April 23, 2002Circulation
Relationship of the TIMI Myocardial Perfusion Grades, Flow Grades, Frame Count, and Percutaneous Coronary Intervention to Long-Term Outcomes After Thrombolytic Administration in Acute Myocardial Infarction
Why the study?
Do improved epicardial flow and tissue-level perfusion at 90 minutes after thrombolytic administration improve 2-year survival in patients with acute myocardial infarction?
Population
Patients with acute myocardial infarction after thrombolytic administration
Design
Cohort
Follow-up
2 years
Authors
Discussion
Loading...
Member takes
Implication
May support perfusion assessment after thrombolysis in AMI; leaves open whether targeted interventions improve survival.
Structured PICO
Do improved epicardial flow and tissue-level perfusion at 90 minutes after thrombolytic administration improve 2-year survival in patients with acute myocardial infarction?
P
Population
Patients with acute myocardial infarction after thrombolytic administration
I
Intervention
Improved epicardial flow (TIMI Flow Grade 2/3 and low Corrected TIMI Frame Counts) and tissue-level perfusion (TIMI Myocardial Perfusion Grade 2/3) at 90 minutes, and rescue percutaneous coronary intervention (PCI)
O
Outcome
2-year survivalhard clinical
Improved epicardial flow and microvascular perfusion after thrombolysis in acute myocardial infarction are independently associated with better long-term survival, highlighting the importance of both macro- and microvascular reperfusion.
Cite This Study
Gibson et al. (2002) studied this question.