Does the class of antihypertensive drug affect the risk of early discontinuation in newly diagnosed hypertensive patients?
Angiotensin II receptor antagonists (AIIAs) have the lowest risk of early discontinuation among newly initiated antihypertensive drugs in general practice.
It is important that general practitioners (GPs) monitor patients closely in the first year following antihypertensive drug initiation, due to the high early risk of discontinuation, and the low percentage of patients who switch to a different antihypertensive drug class after a drug-class discontinuation. AIIA, followed by ACE-I and CCB, had the lowest risk of discontinuation among antihypertensive drug classes.
Burke et al. (Tue,) studied this question.
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