Are prediabetes and type 2 diabetes associated with generalized microvascular dysfunction?
Prediabetes and T2DM are associated with impaired microvascular function in the retina and skin, suggesting that microvascular dysfunction precedes and may contribute to T2DM-associated cardiovascular disease.
Prediabetes, T2DM, and measures of hyperglycemia are independently associated with impaired microvascular function in the retina and skin. These findings support the concept that microvascular dysfunction precedes and thus may contribute to T2DM-associated cardiovascular disease and other complications, which may in part have a microvascular origin such as impaired cognition and heart failure.
Sörensen et al. (Wed,) studied this question.