Majoon Ushba alleviated IL-17A sensitized keratinocyte ferroptosis via JAK-2-STAT-3 signaling axis and reversed imiquimod induced psoriasiform inflammation

Key Points

• The research investigates the mechanisms by which Majoon Ushba alleviates psoriatic inflammation and keratinocyte ferroptosis.
• Examined the impact of Majoon Ushba on IL-17A sensitized keratinocytes
• Analyzed the role of JAK-2-STAT-3 signaling
• Measured inflammatory responses in an imiquimod-induced model of psoriasis
• Majoon Ushba reduced IL-17A induced inflammation in keratinocytes
• The treatment mitigated signs of ferroptosis
• Inhibition of the JAK-2-STAT-3 pathway was observed as a mechanism of action