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April 16, 2026Scientific ReportsOpen Access

Uncovering the antiproliferative potential of Lobophytum pauciflorum metabolites through chemoinformatics and in vitro approaches

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Authors

AAAya Ali AlassassMBMarwa S. Abu BakrAMAsmaa A. Mahmoud

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Overview

Investigates anticancer activity in Lobophytum pauciflorum against human cancer cell lines, suggesting therapeutic potential.

Key Points

  • The research aims to explore the chemical diversity and anticancer properties of Lobophytum pauciflorum metabolites.
  • Utilized chemoinformatics to analyze chemical diversity.
  • Characterized chemical composition using UHPLC-QTOF-MS/MS.
  • Evaluated anticancer activity against eight human cancer cell lines.
  • Determined cytotoxicity with IC₅₀ values for MDA-MB-231 and MCF-7 cells.
  • The extract showed significant cytotoxicity against MDA-MB-231 and MCF-7 cells.
  • IC₅₀ values were 9.46 µg/mL for MDA-MB-231 and 11.59 µg/mL for MCF-7.
  • Findings suggest Lobophytum pauciflorum has potential as an anticancer agent.

Cite This Study

Alassass et al. (2026) studied this question.

synapsesocial.com/papers/69e07bc12f7e8953b7cbd675https://doi.org/10.1038/s41598-026-45881-8
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