Recent weight gain of ≥3 kg was independently associated with reduced odds of elevated estimated pulse wave velocity (≥10 m/s) after adjustment for cardiometabolic risk factors (OR 0.70).
Cross-Sectional (n=14,479)
Does recent body weight change affect arterial stiffness in a general adult population?
Recent weight gain is paradoxically associated with lower estimated pulse wave velocity, though this finding should be interpreted cautiously as ePWV is mathematically derived from age and blood pressure.
Effect estimate: OR 0.70 (95% CI 0.58-0.85)
p-value: p=<0.001
Background and Objectives: Excess body weight is traditionally associated with adverse cardiovascular outcomes, but the relationship between body weight changes and arterial stiffness remains controversial.We investigated the association between recent body weight change and arterial stiffness in a nationally representative Korean population.Methods: This cross-sectional study analyzed data from 14,479 individuals aged 19 years who participated in the 2019-2021 Korea National Health and Nutrition Examination Survey.Body weight change over the preceding year was self-reported and categorized as no change, weight loss (3 kg), or weight gain (3 kg).Arterial stiffness was assessed using estimated pulse wave velocity (ePWV), calculated from age and mean blood pressure (BP).Results: Greater weight loss was associated with higher ePWV in unadjusted analyses, but this association was no longer significant after age adjustment (p=0.656).In contrast, weight gain remained significantly associated with lower ePWV after age adjustment (p<0.001).In logistic regression analyses, weight gain was independently associated with reduced odds of elevated ePWV (10 m/s) after adjustment for age, sex, BP, and cardiometabolic risk factors (odds ratio, 0.70; 95% confidence interval, 0.58-0.85;p<0.001).Conclusions: In this population-based observational study, recent weight gain was associated with lower ePWV, whereas the apparent association between weight loss and higher ePWV was largely explained by age.These findings should be interpreted cautiously because ePWV is a mathematically derived index based on age and BP.
Kim et al. (Thu,) conducted a cross-sectional in General population (n=14,479). Weight gain vs. No weight change was evaluated on Elevated estimated pulse wave velocity (ePWV ≥10 m/s) (OR 0.70, 95% CI 0.58-0.85, p=<0.001). Recent weight gain of ≥3 kg was independently associated with reduced odds of elevated estimated pulse wave velocity (≥10 m/s) after adjustment for cardiometabolic risk factors (OR 0.70).