What question did this study set out to answer?

The study aims to assess the effectiveness and safety of combining bortezomib and bendamustine with high-dose melphalan for patients with relapsed multiple myeloma.

April 16, 2026eJHaemOpen Access

Adding Bortezomib and Bendamustine to High‐Dose Melphalan in Autologous Haematopoietic Stem Cell Transplantation for Relapsed Multiple Myeloma—A Single Centre Retrospective Study

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Authors

TSThomas SilfverbergUppsala University HCHonar CherifUppsala University ESEmma SmittGävle Hospital

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Implication

Retrospective analysis evaluates effectiveness of BBM in relapsed multiple myeloma, suggesting improved outcomes.

Key Points

The study aims to assess the effectiveness and safety of combining bortezomib and bendamustine with high-dose melphalan for patients with relapsed multiple myeloma.
Conducted a retrospective analysis of medical records of 43 patients who received BBM after first-line HDM.
Compared outcomes with a cohort of 43 patients who received HDM before and after the BBM era.
Used Kaplan–Meier estimates to evaluate time to next treatment and progression-free survival.
BBM-treated patients showed a 15% increase in median progression-free survival compared to HDM (p = 0.0122).
Median overall survival after ASCT2 was 72.2 months for BBM compared to 51.5 months for HDM (p = 0.14).
A 26% reduction in time to next treatment was observed for BBM, compared to 39% for HDM in ASCT2.

Cite This Study

Silfverberg et al. (2026) studied this question.

synapsesocial.com/papers/69e07cc02f7e8953b7cbde87 https://doi.org/10.1002/jha2.70288

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Adding Bortezomib and Bendamustine to High‐Dose Melphalan in Autologous Haematopoietic Stem Cell Transplantation for Relapsed Multiple Myeloma—A Single Centre Retrospective Study

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Cite This Study

Adding Bortezomib and Bendamustine to High‐Dose Melphalan in Autologous Haematopoietic Stem Cell Transplantation for Relapsed Multiple Myeloma—A Single Centre Retrospective Study

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Key Points

Cite This Study

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