Evaluation of the Antidepressant Potential of Triplochiton scleroxylon Leaf Extract Using Tail Suspension and Forced Swim Tests

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The aim is to evaluate the antidepressant-like effects of Triplochiton scleroxylon leaf extract and its toxicity profile.
Conducted ethanol maceration of fresh T. scleroxylon leaves resulting in a 14.4% crude extract.
Performed phytochemical screening to identify bioactive compounds.
Assessed acute toxicity using Lorke’s method to determine safety levels.
Evaluated antidepressant-like activity in mice using Tail Suspension Test and Forced Swim Test, comparing various doses of the extract with imipramine.
Phytochemical analysis indicated the presence of flavonoids, alkaloids, tannins, saponins, and steroids.
Acute toxicity tests showed no mortality at 10 and 100 mg/kg, with mortality at 1000 mg/kg.
The extract significantly reduced immobility time in both tests at 45 and 90 mg/kg doses, indicating potential antidepressant effects.

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This evaluation reveals antidepressant-like effects in murine models using Triplochiton scleroxylon leaf extract, suggesting its therapeutic promise.

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Tahir et al. (2026) studied this question.

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