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April 16, 2026Cognitive Affective & Behavioral NeuroscienceOpen Access

Differential brain responses to affective sounds in misophonia and hyperacusis: A task-based fMRI approach

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Authors

NJNamitha JainSAShagun AjmeraSSSomayeh Shahsavarani

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Overview

Task-based fMRI examines brain responses to sounds in misophonia and hyperacusis, suggesting differing neural mechanisms.

Key Points

  • This research aims to differentiate the neural responses in misophonia and hyperacusis when exposed to emotionally charged sounds.
  • Recruited 91 young adults categorized into four groups: misophonia, hyperacusis, comorbid, and controls.
  • Conducted task-based fMRI while participants listened to 90 emotionally valenced sounds and rated their valence.
  • Analyzed whole-brain functional activation and seed-to-voxel functional connectivity.
  • Misophonia showed hyperactivation in visual association areas and reduced connectivity during unpleasant sounds compared to controls.
  • Hyperacusis exhibited reduced connectivity between salience hubs and frontal control regions compared to misophonia and controls.
  • Comorbid group revealed neural patterns reflecting both misophonia and hyperacusis.

Cite This Study

Jain et al. (2026) studied this question.

synapsesocial.com/papers/69e07cc02f7e8953b7cbdf02https://doi.org/10.3758/s13415-026-01435-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Patterns of shared and differential neural activity in misophonia and non-misophonic clinical emotional dysregulation2026
  2. 2Distinguishing Misophonia From Nonclinical Sound Aversion: Emotional Response Profiles for Auditory Triggers2026
  3. 3Resolving competition in auditory cortex: effects of emotional content and misophonia sensitivity2026
  4. 4Resolving Competition in Auditory Cortex: Effects of Emotional Content and Misophonia Sensitivity2025
  5. 5Selective Disruption of Salience‐Network Anterior Insula Connectivity in Misophonia: A Disorder‐Specific Neural Signature2026 · 3 citations